Results
| PMID | 19586841 |
| Gene Name | IL10 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | IL-10-819 (T/C) and -592 (A/C) |
| Population size | 239 |
| Population details | 239 (119 women with different stage Ems, 120 controls) |
| Sex | Female |
| Associated genes | IL-10 |
| Other associated phenotypes |
Endometriosis |
|
Yi Chuan. 2009 May;31(5):479-84. He, Pei| Zhang, Xin-Mei| Deng, Lin| Ma, Jun-Yan The Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China. heipei2@sina.com The purpose of this study was to investigate the relationship between IL-10 promoter gene polymorphism and the susceptibility to endometriosis (EMs) in Chinese population. Amplification refractory mutation system polymerase chain reactions (ARMS-PCR) and DNA sequencing were performed to detect polymorphism of -1082G/A site and PCR-RFLP was used to determine the genotypes in -819T/C and -592A/C sites. One hundred and nineteen Chinese women with different stage EMs and 120 controls were employed in this study. Although there were no significant differences in the polymorphism of -1082 site between two groups (P>0.05), the frequencies of -819C, -592C alleles and -819 CC+TC, -592 CC+AC genotypes were significantly increased in EMs patients compared with the controls (P<0.05). The frequencies of -819C, -592C alleles and -819 CC+TC, -592 CC+AC genotypes were significantly increased in III-IV EMs patients compared with I-IIMs or controls (P<0.01). This suggests that polymorphisms of IL-10-819 (T/C) and -592 (A/C) may be associated with the susceptibility to EMs in Chinese population. Mesh Terms: Adult| Asian Continental Ancestry Group/genetics| Disease Susceptibility/*etiology| Endometriosis/*genetics| Female| *Genetic Predisposition to Disease| Humans| Interleukin-10/*genetics| Polymorphism, Genetic| Polymorphism, Restriction Fragment L |
|